General

The CRC 1286 works interdisciplinary (see research Infrastructure).
It is divided into 3 research areas: Project Area A: A quantitative view of the synaptic compartment, Project Area B: Principles of synaptic function and dysfunction, as well as Project Area C: In silico models of synaptic transmission and plasticity. Furthermore, there are platforms provided by three central projects as well as an associated project.

A1: “The ultrastructure of synapses in action”

Benjamin Cooper

A2: “Structure of synaptic organelles by X-ray diffraction and imaging”

Tim Salditt

A3: “A dynamic analysis of the nanoscale organization of the dendritic spine”

Silvio Rizzoli

A4: “Revealing the ultrastructural changes that determine the development of a CNS synapse”

Carolin Wichmann

A5:“Nanoscale architecture of mitochondria in synapses”

Stefan Jakobs

A6: “Mitochondria function and turnover in synapses”

Peter Rehling

A7: “The organization of the synaptic cytoskeleton”

Elisa D’Este/Stefan Hell

A8: “Regulation of synaptic vesicle cycling by protein phosphorylation and dephosphorylation”

Reinhard Jahn/Henning Urlaub

A9: “SUMOylation in synapses”

Nils Brose

A10: “Protein–protein interactions at the synapse monitored by quantitative protein cross-linking”

Henning Urlaub

B1: “The organization of structural lipids in synaptic membranes”

Nhu Phan

B2: “A microfluidic in vitro approach to study protein mobility in the synapse”

Sarah Köster/Silvio Rizzoli

B3: “Mapping the protein and lipid organization in the plasma membrane of neurons using rapid rupture event imaging”

Andreas Janshoff

B4: “In vitro reconstitution of inhibitory GABAergic postsynapses”

Claudia Steinem

B5: “Quantitative molecular physiology of active zones at calyceal synapses”

Tobias Moser

B6: “The role of RNA in synapse physiology and neurodegeneration”

André Fischer/Tiago Outeiro

B8: “Deciphering the major alpha-synuclein-related alterations in the Parkinson’s disease synapse”

Tiago Outeiro

B9: “Cytoskeletal alterations contributing to synapto-axonal dysfunction in Parkinson’s disease”

Paul Lingor

C1: “Theoretical model of activity-dependent AMPA-receptor dynamics in the synapse”

Christian Tetzlaff

C2: “Dual-purpose optimization theory for the synaptic vesicle cycle”

Fred Wolf

C3: “Modelling dendritic spine fluctuations”

Florentin Wörgötter

Associated project: “Modeling of short-term plasticity of nerve-evoked EPSCs at a glutamatergic synapse”

Erwin Neher

Z2: “Integrative data analysis and interpretation, and generation of a synaptic integrative data strategy (SynIDs)”

Stefan Bonn

Z3: “Simple multi-color super-resolution imaging by 10x expansion microscopy”

Silvio Rizzoli

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