General

Der Sonderforschungsbereich 1286 arbeitet interdisziplinär (siehe Forschungsinfrastruktur) und ist in 3 Forschungsbereiche unterteilt: Projektbereich A: Eine quantitative Ansicht des synaptischen Kompartiments, Projektbereich B: Prinzipien der synaptischen Funktion und Dysfunktion, sowie Projektbereich C: In silico Modelle der synaptischen Übertragung und Plastizität.

Current Projects

A2: “Structure of synaptic organelles by X-ray diffraction and imaging”

Tim Salditt

A3: “Molecular-scale analysis of key points in synaptic activity”

Silvio Rizzoli & Nadja Simeth-Crespi

A4: “Investigating the ultrastructural effects of activity and aging on vesicle recycling and protein turnover”

Carolin Wichmann

A5:“Mitochondrial heterogeneity in synapses”

Stefan Jakobs

A06 / A10: “Mitochondria function and turnover in synapses”

Peter Rehling

A7: “Surface mobility of glutamate receptors”

Elisa D’Este & Stefan Hell

A9: “Syntax of post-translational modifications by UBLs in presynaptic function”

Marilyn Tirard & Nils Brose

A11: “Regulation of synaptic functional heterogeneity and diversity”

Noa Lipstein

A12: “Nanometric architecture of the synaptic cytoskeleton”

Ruben Fernandez-Busnadiego

B2: “The synaptic vesicle cluster as a regulator of presynaptic biomechanics”

Sarah Köster & Sofiia Reshetniak

B4: “In vitro reconstitution of inhibitory GABAergic postsynapses”

Claudia Steinem

B5: “Quantitative molecular physiology of calyceal synapses”

Tobias Moser

B6: “The role of RNA in synapse physiology and neurodegeneration”

Andre Fischer & Tiago Outeiro

B8: “Protein aggregation: markers and drivers of synaptic dysfunction”

Tiago Outeiro

B10: “Nanoscale dynamics and regulation of synapsin conden- sates”

Dragomir Milovanovic

B11 “Gating and expression of long-term synaptic plasticity as an interplay between parallel transmission sites and astrocyte signalling”

Oliver M. Schlüter

C1: “The influence of molecular heterogeneities on liquid phases in the synapse”

Christian Tetzlaff

C2: “Nanoscale geometric focusing of synaptic calcium domains”

Fred Wolf

C3: “The Mechanical Interaction of the Synapse with its Surrounding”

Michael Fauth

C6: “Coarse-grained simulation of the role of local environment on presynaptic release: from fusion to fission”

Marcus Müller

C8: “Experimental and theoretical analysis of single active zone function”

Tobias Moser

C9: “Linking multi-timescale dynamics in the presynapse to neural computation”

Viola Priesemann

C10: “Innovative deep learning approaches enable quantitative analyses of synaptic imaging datasets”

Constantin Pape

Associated project: “Modeling of short-term plasticity of nerve-evoked EPSCs at a glutamatergic synapse”

Erwin Neher

Z2: “Integration of computational models and experimental data”

Stefan Bonn & Christian Tetzlaff

Z4: “Quantitative visualization and analysis of synaptic proteins using nanobodies”

Felipe Opazo

B12 “Super-resolution analysis of neuron-glia interplay at tripartite synapses”

Urs Valentin Nägerl

C11: “Energy optimization as an organizing principle for protein dynamics at the synapse”

Tatjana Tchumatchenko

C12: “A multiscale analysis of synaptic turnover for modeling the dynamic changes that shape synaptic function”

Eugenio Fornasiero & Johanna Senk

Projects 2017 - 2021

B1: “The distribution of structural lipids in synaptic membranes”

Nhu Phan

B3: “Mapping the protein and lipid organization in the plasma membrane of neurons using rapid rupture event imaging”

Andreas Janshoff

B9: “Cytoskeletal alterations contributing to synapto-axonal dysfunction in Parkinson’s disease”

Paul Lingor

Z3: “Simple multi-color super-resolution imaging by 10x expansion microscopy”

Silvio Rizzoli

Projects 2021 - 2025

A1: “Ultrastructure of synapses in action “

Benjamin Cooper

A8: “The role of post-translationally modified proteins in synaptic transmission ”

Henning Urlaub

A10 / A06: “Mitochondria function and turnover in synapses”

Peter Rehling

C5: “The synapse as a complex physical environment”

Stefan Klumpp