We hypothesize that protein clustering is important within synaptic vesicles, allowing the formation of pre-assembled functional units. Such units could efficiently preserve protein interactions critical for vesicle function, thereby facilitating the fast kinetics of the synaptic vesicle cycle. Although emerging evidence suggests that various proteins form clusters on the vesicle membrane, the lack of adequate tools has hindered the detailed study of these nano-compartments to date. We will address this here using cryo-electron tomography (cryo-ET).

Prof. Dr. Ruben Fernandez-Busnadiego

Ruben Fernandez-Busnadiego

Principal Investigators
More subprojects

B9: “Cytoskeletal alterations contributing to synapto-axonal dysfunction in Parkinson’s disease”

Paul Lingor

B3: “Mapping the protein and lipid organization in the plasma membrane of neurons using rapid rupture event imaging”

Andreas Janshoff

B1: “The distribution of structural lipids in synaptic membranes”

Nhu Phan