Synaptic transmission builds on the presynaptic coupling of electrical excitation to transmitter release. Multidomain scaffold proteins of the active zone are thought to govern the topographical organization of vesicular release sites and Ca2+ channels, but this issue is still largely open. We will approach this general issue in the calyceal synapses of the auditory pathway using manipulations of RIM-binding proteins (RIM-BPs) that are key candidate linkers of Ca2+ channels and vesicular release sites.

Tobias Moser

Principal Investigator
More subprojects

Z2: “Integrative data analysis and interpretation, and generation of a synaptic integrative data strategy (SynIDs)”

Stefan Bonn

B8: “Deciphering the major alpha-synuclein-related alterations in the Parkinson’s disease synapse”

Tiago Outeiro

A2: “Structure of synaptic organelles by X-ray diffraction and imaging”

Tim Salditt