Long-term changes of the synaptic strength play a fundamental role in shaping the dynamics of neural networks and they are mainly linked to the variation of the number of bound phosphorylated AMPA receptors (AMPARs) at the postsynaptic site. In this project we will therefore investigate AMPAR-dynamics specifically considering interactions between different plasticity processes. We will develop a concise theoretical model describing the fundamental, plasticity-independent kinetics of AMPARs at the postsynaptic site divided into the postsynaptic density and the extrasynaptic membrane, and we will test it on data from this CRC.

Christian Tetzlaff

Principal Investigator
More subprojects

B2: “A microfluidic in vitro approach to study protein mobility in the synapse”

Sarah Köster/Silvio Rizzoli

A5:“Nanoscale architecture of mitochondria in synapses”

Stefan Jakobs

A1: “The ultrastructure of synapses in action”

Benjamin Cooper