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Long-term changes of the synaptic strength play a fundamental role in shaping the behaviorally relevant dynamics of neuronal networks. In the first funding period, we developed a theoretical model of AMPA receptor trafficking in the postsynaptic site, considering a fixed network of scaffolding proteins. In the second funding period, we plan to extend our analysis to the plasticity-dependent, spatiotemporal dynamics of AMPA receptors interacting with diffusible scaffolding proteins, in a dynamic postsynaptic density.

Dr. Christian Tetzlaff

Christian Tetzlaff

Principal Investigator
More subprojects

B9: “Cytoskeletal alterations contributing to synapto-axonal dysfunction in Parkinson’s disease”

Paul Lingor

Z3: “Simple multi-color super-resolution imaging by 10x expansion microscopy”

Silvio Rizzoli

B1: “The distribution of structural lipids in synaptic membranes”

Nhu Phan