There is now ample evidence that not only coding but also non-coding RNAs play important roles in cellular plasticity. This is particularly true for neurons, where for example mRNAs are locally transcribed at (post)synapses. We will use the mouse as our model organism, and we will specifically address the question of whether RNA-based processes contribute to synaptic dysfunction during aging and in neurodegenerative disease, especially in Parkinson’s Disease.

André Fischer

Principal Investigator

Tiago Outeiro

Principal Investigator
More subprojects

A2: “Structure of synaptic organelles by X-ray diffraction and imaging”

Tim Salditt

B8: “Deciphering the major alpha-synuclein-related alterations in the Parkinson’s disease synapse”

Tiago Outeiro

B4: “In vitro reconstitution of inhibitory GABAergic postsynapses”

Claudia Steinem