There is ample evidence that RNAs are localized at synapses, both mRNAs and non-coding RNAs, such as microRNAs. A number of findings also suggest that shuttling of RNA amongst neural cells, and processes such as dynamic RNA modification via N6-methyl-adenosine-methylation (m6A), play a role in controlling synaptic plasticity. We will continue our study of these phenomena during the second funding period, focusing on the healthy and diseased brain, in both Parkinson and Alzheimer Disease models.

Prof. Dr. Andre Fischer

André Fischer

Principal Investigator
Prof. Dr. Tiago Fleming Outeiro

Tiago Outeiro

Principal Investigator
More subprojects

B9: “Cytoskeletal alterations contributing to synapto-axonal dysfunction in Parkinson’s disease”

Paul Lingor

B3: “Mapping the protein and lipid organization in the plasma membrane of neurons using rapid rupture event imaging”

Andreas Janshoff

B1: “The distribution of structural lipids in synaptic membranes”

Nhu Phan