There is now ample evidence that not only coding but also non-coding RNAs play important roles in cellular plasticity. This is particularly true for neurons, where for example mRNAs are locally transcribed at (post)synapses. We will use the mouse as our model organism, and we will specifically address the question of whether RNA-based processes contribute to synaptic dysfunction during aging and in neurodegenerative disease, especially in Parkinson’s Disease.

André Fischer

Principal Investigator

Tiago Outeiro

Principal Investigator
More subprojects

Z3: “Simple multi-color super-resolution imaging by 10x expansion microscopy”

Silvio Rizzoli

B2: “A microfluidic in vitro approach to study protein mobility in the synapse”

Sarah Köster/Silvio Rizzoli

A5:“Nanoscale architecture of mitochondria in synapses”

Stefan Jakobs