We currently lack an overall understanding of the kinetic processes of vesicle-protein interactions. The mobility and diffusivity of proteins is very likely altered by the presence of binding partners such as vesicles, but there is little quantitative information available on this process. To solve this problem, we will combine controlled confining geometries in microfluidic environments with direct in situ single molecule imaging, relying on purified synaptic vesicles and proteins.

Sarah Köster

Principal Investigator

Silvio Rizzoli

Principal Investigator
More subprojects

Z3: “Simple multi-color super-resolution imaging by 10x expansion microscopy”

Silvio Rizzoli

A6: “Mitochondria function and turnover in synapses”

Peter Rehling

A4: “Revealing the ultrastructural changes that determine the development of a CNS synapse”

Carolin Wichmann