We will provide (i) the initial analysis of high-throughput transcriptomic and proteomic data and (ii) the integration of this data for the detection of key proteins, network hubs, and relevant pathways. We will also address a second major challenge for this CRC, by designing the Synaptic Integrative Data Strategy (SynIDs) that allows for the querying of results over data modalities, and will support causal reasoning. SynIDs should enable researchers to query across imaging, electrophysiological, molecular, and clinical data, and to mix and combine information from public resources to build hypotheses that can be experimentally validated.

Stefan Bonn

Principal Investigator
More subprojects

A10: “Protein–protein interactions at the synapse monitored by quantitative protein cross-linking”

Henning Urlaub

A4: “Revealing the ultrastructural changes that determine the development of a CNS synapse”

Carolin Wichmann

B4: “In vitro reconstitution of inhibitory GABAergic postsynapses”

Claudia Steinem