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Synaptic transmission relies on a dedicated protein machinery that functions in concert to mediate all aspects of neurotransmission. Synapse subtypes differ from one another in structural and functional aspects, and they change continuously during development, plasticity and disease. To understand how the synaptic proteome is changed in different synapses, and in different activity states, we will rely the combination of proximity biotinylation methods with genetic manipulations in mouse models.

Noa Henia Lipstein-Thoms Ph.D

Noa Lipstein

Principal Investigator
More subprojects

Z3: “Simple multi-color super-resolution imaging by 10x expansion microscopy”

Silvio Rizzoli

B3: “Mapping the protein and lipid organization in the plasma membrane of neurons using rapid rupture event imaging”

Andreas Janshoff

B9: “Cytoskeletal alterations contributing to synapto-axonal dysfunction in Parkinson’s disease”

Paul Lingor

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