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In the first funding period, we have developed a mathematical model that describes the spatio-temporal processes of the dynamic pool of actin filaments from the postsynaptic spines in basal, resting conditions. In the second funding period, we will focus on synaptic plasticity and the role of actin-driven structural changes in this process. We will rely on the “tagging and capture hypothesis”, in which we see actin dynamics as a tag that in critical for synaptic plasticity.