In this project, we use a theoretical approach to understand the implications of spine shape fluctuation on information retention by an individual synapse. We hypothesize that the dependence between shape fluctuations and the initial shape might give rise to attractive states, which prolong the timescale on which a single synapse can retain information. To test this hypothesis, we aim to create a model based on the molecular mechanisms governing the changes in spine geometry, i.e. the dynamics of the scaffolding protein actin and its activity-dependent regulation.

Florentin Wörgötter

Principal Investigator
More subprojects

B9: “Cytoskeletal alterations contributing to synapto-axonal dysfunction in Parkinson’s disease”

Paul Lingor

Z3: “Simple multi-color super-resolution imaging by 10x expansion microscopy”

Silvio Rizzoli

B6: “The role of RNA in synapse physiology and neurodegeneration”

André Fischer/Tiago Outeiro