Many studies employing various ways of perturbation have shown that the synaptic cytoskeleton has an extremely important role in synapse formation, synaptic plasticity, and the dynamics of many synaptic organelles, such as synaptic vesicles. However, the exact distribution of cytoskeleton components and their interplay within synapses are essentially unknown. In this project, we will elucidate the localization and roles of these cytoskeletal elements by combining super-resolution microscopy with an analysis of live-cell dynamics.

Elisa D'Este

Principal Investigator

Stefan Hell

Principal Investigator
More subprojects

B3: “Mapping the protein and lipid organization in the plasma membrane of neurons using rapid rupture event imaging”

Andreas Janshoff

Z2: “Integrative data analysis and interpretation, and generation of a synaptic integrative data strategy (SynIDs)”

Stefan Bonn

B9: “Cytoskeletal alterations contributing to synapto-axonal dysfunction in Parkinson’s disease”

Paul Lingor