Many studies employing various ways of perturbation have shown that the synaptic cytoskeleton has an extremely important role in synapse formation, synaptic plasticity, and the dynamics of many synaptic organelles, such as synaptic vesicles. However, the exact distribution of cytoskeleton components and their interplay within synapses are essentially unknown. In this project, we will elucidate the localization and roles of these cytoskeletal elements by combining super-resolution microscopy with an analysis of live-cell dynamics.

Elisa D'Este

Principal Investigator

Stefan Hell

Principal Investigator
More subprojects

A4: “Revealing the ultrastructural changes that determine the development of a CNS synapse”

Carolin Wichmann

Associated project: “Modeling of short-term plasticity of nerve-evoked EPSCs at a glutamatergic synapse”

Erwin Neher

B1: “The organization of structural lipids in synaptic membranes”

Nhu Phan