Mitochondria occupy approximately 30% of synapse volume (on the presynaptic side) and are thought to provide the ATP that is essential for synaptic vesicle trafficking. However, little is known on their activity state, protein biogenesis, and turnover in the synapse. This project aims to close this gap in our understanding of the functional characteristics of synaptic mitochondria. We will carry out a comprehensive analysis of the protein composition of mitochondrial in the synapse, will determine to what extent protein biogenesis occurs in synapses, and we will determine the protein stability of synaptic mitochondria.

Peter Rehling

Principal Investigator
More subprojects

C3: “Modelling dendritic spine fluctuations”

Florentin Wörgötter

Z2: “Integrative data analysis and interpretation, and generation of a synaptic integrative data strategy (SynIDs)”

Stefan Bonn

A3: “A dynamic analysis of the nanoscale organization of the dendritic spine”

Silvio Rizzoli