One-step nanoscale expansion microscopy reveals individual protein shapes
Ali H. Shaib, Abed Alrahman Chouaib, Rajdeep Chowdhury, Jonas Altendorf, Daniel Mihaylov, Chi Zhang, Donatus Krah, Vanessa Imani, Russell KW Spencer, Svilen Veselinov Georgiev, Nikolaos Mougios, Mehar Monga, Sofiia Reshetniak, Tiago Mimoso, Han Chen, Parisa Fatehbasharzad, Dagmar Crzan, Kim-Ann Saal, Mohamad Mahdi Alawieh, Nadia Alawar, Janna Eilts, Jinyoung Kang, Alireza Soleimani, Marcus Müller, Constantin Pape, Luis Alvarez, Claudia Trenkwalder, Brit Mollenhauer, Tiago F Outeiro, Sarah Köster, Julia Preobraschenski, Ute Becherer, Tobias Moser, Edward S. Boyden, A. Radu Aricescu, Markus Sauer, Felipe Opazo, Silvio O. Rizzoli (2024)
The synaptic vesicle cluster as a controller of pre- and postsynaptic structure and function
Sofiia Reshetniak, Cristian A. Bogaciu, Stefan Bonn, Nils Brose, Benjamin H. Cooper, Elisa D’Este, Michael Fauth, Rubén Fernández-Busnadiego, Maksims Fiosins, André Fischer, Svilen V. Georgiev, Stefan Jakobs, Stefan Klumpp, Sarah Köster, Felix Lange, Noa Lipstein, Victor Macarrón-Palacios, Dragomir Milovanovic, Tobias Moser, Marcus Müller, Felipe Opazo, Tiago F. Outeiro, Constantin Pape, Viola Priesemann, Peter Rehling, Tim Salditt, Oliver Schlüter, Nadja Simeth, Claudia Steinem, Tatjana Tchumatchenko, Christian Tetzlaff, Marilyn Tirard, Henning Urlaub, Carolin Wichmann, Fred Wolf, Silvio O. Rizzoli (2024)
The DNA-PAINT palette: a comprehensive performance analysis of fluorescent dyes
Philipp R. Steen, Eduard M. Unterauer, Luciano A. Masullo, Jisoo Kwon, Ana Perovic, Kristina Jevdokimenko, Felipe Opazo, Eugenio F. Fornasiero, Ralf Jungmann (2024)
Paralemmin-1 controls the nanoarchitecture of the neuronal submembrane cytoskeleton
Victor Macarrón-Palacios, Jasmine Hubrich, Maria Augusta do Rego Barros Fernandes Lima, NicoleG. Metzendorf, Simon Kneilmann, Marleen Trapp, Claudio Acuna, Annarita Patrizi, Elisa D’Este, Manfred W. Kilimann (2024)
Peripheral whole blood microRNA expression in relation to vascular function: a population-based study
Valentina Talevi, Konstantinos Melas, Gökhan Pehlivan, Mohammed A. Imtiaz, Dennis Manfred Krüger, Tonatiuh Pena Centeno, N. Ahmad Aziz, Andre Fischer, Monique M.B. Breteler (2024)
PRDM16-DT: A Brain and Astrocyte-Specific lncRNA Implicated in Alzheimer’s Disease
Sophie Schröder, Ulrike Fuchs, Verena Gisa, Tonatiuh Pena, Dennis M Krüger, Nina Hempel, Susanne Burkhardt, Gabriela Salinas, Anna Lena Schütz, Ivana Delalle, Farahnaz Sananbenesi, Andre Fischer (2024)
The lack of synapsin alters presynaptic plasticity at hippocampal mossy fibers in male mice
Felicitas Bruentgens, Laura Moreno Velasquez, Alexander Stumpf, Daniel Parthier, Jörg Breustedt, Fabio Benfenati, Dragomir Milovanovic, Dietmar Schmitz, Marta Orlando (2024)
Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic target
Lucas Caldi Gomes, Sonja Hänzelmann, Fabian Hausmann, Robin Khatri, Sergio Oller, Mojan Parvaz, Laura Tzeplaeff, Laura Pasetto, MarieGebelin, Melanie Ebbing, Constantin Holzapfel, Stefano Fabrizio Columbro, Serena Scozzari, Johanna Knöferle, IsabellCordts, Antonia F. Demleitner, Marcus Deschauer, Claudia Dufke, Marc Sturm, Qihui Zhou, Pavol Zelina, Emma Sudria-Lopez, Tobias B. Haack, Sebastian Streb, Magdalena Kuzma-Kozakiewicz, Dieter Edbauer, R. Jeroen Pasterkamp, Endre Laczko, Hubert Rehrauer, Ralph Schlapbach, Christine Carapito, Valentina Bonetto, Stefan Bonn, Paul Lingor (2024)
Nanobodies against the myelin enzyme CNPase as tools for structural and functional studies
Sigurbjörn Markusson, Arne Raasakka, Marcel Schröder, Shama Sograte-Idrissi, Amir Mohammad Rahimi, Ommolbanin Asadpour, Henrike Körner, Dmitri Lodygin, Maria A. Eichel-Vogel, Risha Chowdhury, Aleksi Sutinen, Manasi Iyer, Madeline H. Cooper, Maya K. Weigel, Nicholas Ambiel, Hauke B. Werner, J. Bradley Zuchero, Felipe Opazo, Petri Kursul (2024)
Integrative Analysis of miRNA Expression Profiles Reveals Distinct and Common Molecular Mechanisms Underlying Broad Diagnostic Groups of Severe Mental Disorders
Jeremie Poschmann, Pierre Solomon, Lalit Kaurani, Monika Budde …. Andre Fischer, Urs Helbronner (2024)
An aldehyde-crosslinking mitochondrial probe for STED imaging in fixed cells
Jingting Chen, Till Stephan, Felix Gaedke, Tianyan Liu, Yiyan Li, Astrid Schauss, Peng Chen, Veronika Wulff, Stefan Jakobs, Christian Jüngst, Zhixing Chen (2024)
A role for astrocytic miR-129-5p in Frontotemporal Dementia.
Lalit Kaurani, Ranjit Pradhan, Sophie Schröder, Susanne Burkhardt, Anna-Lena Schuetz, Dennis M. Krüger, Tonatiuh Pena, Peter Heutink, Farahnaz Sananbenesi, Andre Fischer (2024)
α-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrPC-CCR5 dependent pathway
Marina I. Oliveira da Silva, Miguel Santejo, Isaac W. Babcock, Ana Magalhaes, Lauria S. Minamide, Seok Joon Won, Erika Castillo, Ellen Gerhardt, Christiane Fahlbuch, Raymond A. Swanson, Tiago F. Outeiro, Ricardo Taipa, Michael Ruff, James R. Bamburg, Marcia A. Liz (2024)
Three-dimensional multi-target super-resolution microscopy of cells using Metal-Induced Energy Transfer and DNA-PAINT
Nazar Oleksiievets, Mougios, Daniel C. Jans, Lara Hauke, Jan Christoph Thiele, Samrat Basak, Stefan Jakobs, Felipe Opazo, Jörg Enderlein, Roman Tsukanov (2024)
Complexin has a dual synaptic function as checkpoint protein in vesicle priming and as a promoter of vesicle fusion
Francisco José López-Murcia, Kun-Han Lin, Manon M. M. Berns, Mrinalini Ranjan, Noa Lipstein, Erwin Neher, Nils Brose, Kerstin Reim, Holger Taschenberger (2024)
Spatial proteomics in neurons at single-protein resolution
Eduard M. Unterauer, Sayedali Shetab Boushehri, Kristina Jevdokimenko, Luciano A. Masullo, Mahipal Ganji, Shama Sograte-Idrissi, Rafal Kowalewsk, Sebastian Strauss, Susanne C.M. Reinhardt, Ana Perovic, Carsten Mar, Felipe Opazo, Eugenio F. Fornasiero, Ralf Jungmann (2024)
Formation of memory assemblies through the DNA-sensing TLR9 pathway
Vladimir Jovasevic, Elizabeth M. Wood, Ana Cicvaric, Hui Zhang, Zorica Petrovic, Anna Carboncino, Kendra K. Parker, Thomas E. Bassett, Maria Moltesen, Naoki Yamawaki, Hande Login, Joanna Kalucka, Farahnaz Sananbenesi,Xusheng Zhang, Andre Fischer, Jelena Radulovic (2024)
Regulation of Zbp1 by miR-99b-5p in microglia controls the development of schizophrenia-like symptoms in mice
Lalit Kaurani, Md Rezaul Islam, Urs Heilbronner, Dennis M Krüger, Jiayin Zhou, Aditi Methi, Judith Strauss, Ranjit Pradhan, Sophie Schröder, Susanne Burkhardt, Anna-Lena Schuetz, Tonatiuh Pena, Lena Erlebach, Anika Bühler, Monika Budde, Fanny Senner, Mojtaba Oraki Kohshour, Eva C Schulte, Max Schmauß, Eva Z Reininghaus, Georg Juckel, Deborah Kronenberg-Versteeg, Ivana Delalle, Francesca Odoardi, Alexander Flügel, Thomas G Schulze, Peter Falkai, Farahnaz Sananbenesi, Andre Fischer (2024)
Inhibition of 26S proteasome activity by α-synuclein is mediated by the proteasomal chaperone Rpn14/PAAF1
Dajana Galka, Tariq T. Ali, Alexander Bast, Marie Niederleithinger, Ellen Gerhardt, Ryo Motosugi, Eri Sakata, Michael Knop, Tiago F. Outeiro, Blagovesta Popova, Gerhard H. Braus (2024)
Subcellular Protein Turnover in Human Neural Progenitor Cells Revealed by Correlative Electron Microscopy and Nanoscale Secondary Ion Mass Spectrometry Imaging
Alicia A. Lork, Stefania Rabasco, Carl Ernst, André du Toit, Silvio O. Rizzoli, Nhu T. N. Phan (2024)
Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid
Liam D. Aubrey, Natalia Ninkina, Sabine M. Ulamec, Natalia Y. Abramycheva, Eftychia Vasili, Oliver M. Devine, Martin Wilkinson, Eilish Mackinnon, Galina Limorenko, Martin Walko, Sarah Muwanga, Leonardo Amadio, Owen M. Peters, Sergey N. Illarioshkin, Tiago F. Outeiro, Neil A. Ranson, David J. Brockwell, Vladimir L. Buchman, Sheena E. Radford (2024)
Region-Specific Phosphorylation Determines Neuroligin-3 Localization to Excitatory Versus Inhibitory Synapses
Bekir Altas, Liam P. Tuffy, Annarita Patrizi, Kalina Dimova, Tolga Soykan, Cheryl Brandenburg, Andrea J. Romanowski, Julia R. Whitten, Colin D. Robertson, Saovleak N. Khim, Garrett W. Crutcher, Mateusz C. Ambrozkiewicz, Oleksandr Yagensky, Dilja Krueger-Burg, Matthieu Hammer, He-Hsuan Hsiao, Pawel R. Laskowski, Lydia Dyck, Adam C. Puche, Marco Sassoè-Pognetto, John J.E. Chua, Henning Urlaub, Olaf Jahn, Nils Brose, Alexandros Poulopoulos (2023)
Lipid vesicle pools studied by passive X-ray microrheology
Titus Czajka, Charlotte Neuhaus, Jette Alfken, Moritz Stammer, Yuriy Chushkin, Diego Pontoni, Christian Hoffmann, Dragomir Milovanovic, Tim Salditt (2023)
Excess phosphoserine-129 α-synuclein induces synaptic vesicle trafficking and declustering defects at a vertebrate synapse
Jaqulin N. Wallace, Zachary C. Crockford, Cristina Román-Vendrell, Emily B. Brady, Christian Hoffmann, Karina J. Vargas, Mariana Potcoava, M. Elizabeth Wegman, Simon T. Alford, Dragomir Milovanovic, Jennifer R. Morgan (2023)
Mammalian oocytes store proteins for the early embryo on cytoplasmic lattices.
Ida M.A. Jentoft, Felix J.B. Bäuerlein, Luisa M. Welp, Benjamin H. Cooper, Arsen Petrovic, Chun So, Sarah Mae Penir, Antonio Z. Politi, Yehor Horokhovskyi, Iina Takala, Heike Eckel, Rüdiger Moltrecht, Peter Lénárt, Tommaso Cavazza, Juliane Liepe, Nils Brose, Henning Urlaub, Rubén Fernández-Busnadiego, Melina Schuh (2023)
Neuronal activity modulates the incorporation of newly translated PSD-95 into a robust structure as revealed by STED and MINFLUX
Clara-Marie Gürth, Maria Augusta do Rego Barros Fernandes Lima, Victor Macarrón Palacios, Jasmine Hubrich, Angel Rafael Cereceda Delgado, Nikolaos Mougios, Opazo, Elisa D’Este (2023)
Katja Thümmler, Claudia Wrzos, Jonas Franz, Daniel McElroy, John J. Cole, Lorna Hayden, Diana Arseni, Friedrich Schwarz, Andreas Junker, Julia M. Edgar, Sebastian Kügler, Andreas Neef, Fred Wolf, Christine Stadelmann, Christopher Linington (2023)
Increased alpha-synuclein and neuroinflammation in the substantia nigra triggered by systemic inflammation are reversed by targeted inhibition of the receptor for advanced glycation end products (RAGE).
Daniel Oppermann Peixoto, Reykla Ramon Bittencourt, Juciano Gasparotto, Flávio Gabriel Carazza Kessler, Pedro Ozorio Brum, Nauana Somensi, Carolina Saibro Girardi, Lucas dos Santos da Silva, Tiago F. Outeiro, José Cláudio Fonseca Moreira, Daniel Pens Gelain (2023)
A viral ADP-ribosyltransferase attaches RNA chains to host proteins
Maik Wolfram-Schauerte, Nadiia Pozhydaieva, Julia Grawenhoff, Luisa M. Welp, Ivan Silbern, Alexaner Wulf, Franziska A. Billau, Timo Glatter, Henning Urlaub, Andres Jäschke, Katharina Höfer (2023)
Age-dependent structural reorganization of utricular ribbon synapses
Susann Michanski, Timo Henneck, Mohona Mukhopadhyay, Anna M. Steyer, Paola Agüi Gonzalez, Katharina Grewe, Peter Ilgen, Mehmet Gültas, Eugeno F. Fornasiero, Stefan Jakobs, Wiebke Möbius, Christian Vogl, Tina Pangrsic, Silvio O. Rizzoli, Carolin Wichmann (2023)
Metabolic switch from fatty acid oxidation to glycolysis in knock‐in mouse model of Barth syndrome
Arpita Chowdhury, Angela Boshnakovska, Abhishek Aich, Aditi Methi, Ana Maria Vergel Leon, Ivan Silbern, Christian Lüchtenborg, Lukas Cyganek, Jan Prochazka, Radislav Sedlacek, Jiri Lindovsky, Dominic Wachs, Zuzana Nichtova, Dagmar Zudova, Gizela Koubkova, André Fischer, Henning Urlaub, Britta Brügger, Dörthe M Katschinski, Jan Dudek, Peter Rehling (2023)
Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease
Carmina C. Warth Perez Arias, Ivan Silbern, Lucas Caldi Gomes, Hannes Wartmann, Vivian Dambeck, Jonas Fanz, Lisa Neuenroth, Mathias Bähr, Tiago F. Outeiro, Stefan Bonn, Christine Stadelmann-Nessler, Silvio O. Rizzoli, Christof Lenz, Henning Urlaub, Paul (2023)
A Versatile Synaptotagmin-1 Nanobody Provides Perturbation-Free Live Synaptic Imaging And Low Linkage-Error in Super-Resolution Microscopy
Karine Queiroz Zetune Villa Real, Nikolaos Mougios, Ronja Rehm, Shama Sograte-Idrissi, László Albert, Amir Mohammad Rahimi, Manuel Maidorn, Jannik Hentze, Markel Martínez-Carranza, Hassan Hosseini, Kim-Ann Saal, Nazar Oleksiievets, Matthias Prigge, Roman Tsukanov, Pål Stenmark, Eugenio F. Fornasiero, Felipe Opazo (2023)
Is it all the RAGE? Defining the role of the receptor for advanced glycation end products in Parkinson's disease
Juciano Gasparotto, Nauana Somensi, Carolina Saibro Girardi, Reykla Ramon Bittencourt, Laura Martinewski de Oliveira, Laura Piloneto Hoefel, Ingrid Matsubara Scheibel, Daniel Oppermann Peixoto, José Claudio Fonseca Moreira, Tiago Fleming Outeiro, Daniel Pens Gelain (2023)
Spatial proteomics in neurons at single-protein resolution
Eduard M. Unterauer, Sayedali Shetab Boushehri, Kristina Jevdokimenko, Luciano A. Masullo, Mahipal Ganji, Shama Sograte-Idrissi, Rafal Kowalewski, Sebastian Strauss, Susanne C.M. Reinhardt, Ana Perovic, Carsten Marr, Felipe Opazo, Eugenio F. Fornasiero, Ralf Jungmann (2023)
Dominik Kylies, Marina Zimmermann, Fabian Haas, Maria Schwerk, Malte Kuehl, Michael Brehler, Jan Czogalla, Lola C. Hernandez, Leonie Konczall, Yusuke Okabayashi, Julia Menzel, Ilka Edenhofer, Sam Mezher, Hande Aypek, Bernhard Dumoulin, Hui Wu, Smilla Hofmann, Oliver Kretz, Nicola Wanner, Nicola M. Tomas, Susanne Krasemann, Markus Glatzel, Christoph Kuppe, Rafael Kramann, Bella Banjanin, Rebekka K. Schneider, Christopher Urbschat, Petra Arck, Nicola Gagliani, Marc van Zandvoort, Thorsten Wiech, Florian Grahammer, Pablo J. Sáez, Milagros N. Wong, Stefan Bonn, Tobias B. Huber, Victor G. Puelles (2023)
Towards a Biological Definition of Parkinson’s Disease
Günter U. Höglinger, Charles H. Adler, Daniela Berg, Christine Klein, Tiago F. Outeiro, Werner Poewe, Ronald Postuma, Jon Stoessl, Anthony E. Lang (2023)
Characterizing the differential distribution and targets of Sumo1 and Sumo2 in the mouse brain
Terry R. Suk, Trina T. Nguyen, Zoe A. Fisk, Miso Mitkovski, Haley M. Geertsma, Jean-Louis A. Parmasad, Meghan M. Heer, Steve M. Callaghan, Fritz Benseler, Nils Brose, Marilyn Tirard, Maxime W.C. Rousseaux (2023)
Anna Antoniou, Loic Auderset, Lalit Kaurani, Eva Sebastian, Yuzhou Zeng, Maria Allahham, Silvia Cases-Cunillera, Susanne Schoch, Jan Gründemann, Andre Fischer, Anja Schneider (2023)
A versatile synaptotagmin-1 nanobody provides perturbation-free live synaptic imaging and low linkage-error in super-resolution microscopy
Karine Queiroz Zetune Villa Real, Nikolaos Mougios, Ronja Rehm, Shama Sograte-Idrissi, László Albert, Amir Mohammad Rahimi, Manuel Maidorn, Jannik Hentze, Markel Martínez-Carranza, Hassan Hosseini, Kim-Ann Saal, Nazar Oleksiievets, Matthias Prigge, Roman Tsukanov, Pål Stenmark, Eugenio F. Fornasiero, Felipe Opazo (2023)
Phase Separation in Biology and Disease; Current Perspectives and Open Questions
Steven Boeynaems, Shasha Chong, Jörg Gsponer, Liam Holt, Dragomir Milovanovic, Diana M. Mitre, Oliver Mueller-Cajar, Bede Portz, John F. Reilly, Christopher D. Reinkemeier, Benjamin R. Sabari, Serena Sanulli, James Shorter, Emily Sontag, Lucia Strader, Jeanne Stachowiak, Stephanie C. Weber, Michael White, Huaiying Zhang, Markus Zweckstetter, Shana Elbaum-Garfinkle, Richard Kriwacki (2023)
Neurodegenerative disease of the brain: a survey of interdisciplinary approaches
Franca Davenport, John Gallacher, Zoe Kourtzi, Ivan Koychev, Paul M. Matthews, Neil P. Oxtoby, Laura M. Parkes, Viola Priesemann, James B. Rowe, Stephen W. Smye, Henrik Zetterberg (2023)
Age-dependent structural reorganization of utricular ribbon synapses
Susann Michanski, Timo Henneck, Mohona Mukhopadhyay, Anna M. Steyer, Paola Agüi Gonzalez, Katharina Grewe, Peter Ilgen, Mehmet Gültas, Eugeno F. Fornasiero, Stefan Jakobs, Wiebke Möbius, Christian Vogl, Tina Pangrsic, Silvio O. Rizzoli, Carolin Wichmann (2023)
ERR2 and ERR3 promote the development of gamma motor neuron functional properties required for proprioceptive movement control
Mudassar N. Khan, Pitchaiah Cherukuri, Francesco Negro, Ashish Rajput, Piotr Fabrowski, Vikas Bansal, Camille Lancelin, Tsung-I Lee, Yehan Bian, William P. Mayer, Turgay Akay, Daniel Müller, Stefan Bonn, Dario Farina, Till Marquardt (2022)
Focused ion beam-scanning electron microscopy links pathological myelin outfoldings to axonal changes in mice lacking Plp1 or Mag
Anna M. Steyer, Tobias J. Buscham, Charlotta Lorenz, Sophie Hümmert, Maria A. Eichel-Vogel, Leonie C. Schadt, Julia M. Edgar, Sarah Köster, Wiebke Möbius, Klaus-Armin Nave, Hauke B. Werner (2022)
The future of Parkinson’s disease research: A new paradigm of human specific investigation is necessary… and possible.
Manuela Cassotta, Hugo Geerts, Lise Harbom, Tiago F. Outeiro, Iosif Pediaditakis, Orly Reiner, Stefan Schildknecht, Jens C. Schwamborn, Jarrod Bailey, Kathrin Herrmann, Helena T. Hogberg (2022)
Ectosomes and exosomes modulate neuronal spontaneous activity
Inês C. Brás, Mohammad H. Khani, Dietmar Riedel, Iwan Parfentev, Ellen Gerhardt, Christoph van Riesen, Henning Urlaub, Tim Gollisch, Tiago F. Outeiro (2022)
JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species
Cleonice Creusa Santos, Thyago R. Cardim‑Pires, Liana Shvachiy, Luis Arturo Fonseca‑Fonseca, Patricia Munoz, Aurea Maria A. N. Almeida, Ana Carla S. Costa, Jessica Teles‑Souza, Estael Ochoa‑Rodriguez, Maria de Fatima Dias Costa, Fernando L. Palhano, Juan Segura‑Aguilar, Deyse B. Barbosa, Mayra R. do Bomfim, Manoelito C. dos Santos Junior, Franco Henrique A. Leite, Samuel Silva da Rocha Pita, Silvia Lima Costa, Yanier Nunez‑Figueredo, Tiago F. Outeiro, Debora Foguel, Victor Diogenes Amaral Silva (2022)
Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies
David J. Koss, Daniel Erskine, Andrew Porter, Pawel Palmoski, Hariharan Menon, Olivia G. J. Todd, Marta Leite, Johannes Attems, Tiago F. Outeiro (2022)
Aromaticity at position 39 in α-synuclein: A modulator of amyloid fibril assembly and membrane-bound conformations
Fiamma A. Buratti, Nicola Boeffinger, Hugo A. Garro, Jesica S. Flores, Francisco J. Hita, Phelippe do Carmo Gonçalves, Federico dos Reis Copello, Leonardo Lizarraga, Giulia Rossetti, Paolo Carloni, Markus Zweckstetter, Tiago F. Outeiro, Stefan Eimer, Christian Griesinger, Claudio O. Fernández (2022)
Conserved reduction of m6A marks during aging and neurodegeneration is linked to altered translation of synaptic transcripts
Ricardo Castro-Hernández, Tea Berulava, Maria Metelova, Robert Epple, Tonatiuh Peña Centeno, M Sadman Sakib, Susanne Burkhart, Momchil Ninov, Katherine E. Bohnsack, Markus T. Bohnsack, Ivana Delalle, Andre Fischer (2023)
Published 10. June 2022
BioRxiv
https://doi.org/10.1101/2022.06.08.495100
now published 22. February 2023, PNAS
https://doi.org/10.1073/pnas.2204933120
Alpha-synuclein overexpression induces epigenomic dysregulation of glutamate signaling and locomotor pathways
http://dx.doi.org/10.1093/hmg/ddac104
Samantha L Schaffner, Zinah Wassouf, Diana F Lazaro, Mary Xylaki, Nicole Gladish, David T S Lin, ulia MacIsaac, Katia Ramadori, Thomas Hentrich, Julia M Schulze-Hentrich, Tiago F Outeiro, Michael S Kobor (2022)
Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses.
Rituparna Chakrabarti, Lina María Jaime Tobón, Loujin Slitin, Magdalena Redondo Canales, Gerhard Hoch, Marina Slashcheva, Elisabeth Fritsch, Kai Bodensiek, Özge Demet Özçete, Mehmet Gültas, Susann Michanski, Felipe Opazo, Jakob Neef, Tina Pangrsic, Tobias Moser, Carolin Wichmann
Glycation modulates glutamatergic signaling and exacerbates Parkinson’s disease-like phenotypes
Ana Chegão, Mariana Guarda, Bruno M. Alexandre, Liana Shvachiy, Mariana Temido-Ferreira, Inês Marques-Morgado, Bárbara Fernandes Gomes, Rune Matthiesen, Luísa V. Lopes, Pedro R. Florindo, Ricardo A. Gomes, Patrícia Gomes-Alves, Joana E. Coelho, Tiago F Outeiro, Hugo Vicente Miranda (2022)
Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3
Neha Upmanyu, Jialin Jin, Henrik von der Emde, Marcelo Ganzella, Leon Bösche, Viveka Nand Malviya, Evi Zhuleku, Antonio Zaccaria Politi, Momchil Ninov, Ivan Silbern, Marcel Leutenegger, Henning Urlaub, Dietmar Riedel, Julia Preobraschenski, Ira Milosevic, Stefan W.Hell, Reinhard Jahn, Sivakumar Sambandan (2022)
Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation
Laura Torres-Garcia, Joana M.P. Domingues, Edoardo Brandi, Caroline Haikal, Janitha M. Mudannayake, Ines C. Bras, Ellen Gerhardt, Wen Li, Alexander Svanbersson, Tiago F. Outeiro, Gunnar K. Gouras (2022)
Co-localization of different neurotransmitter transporters on synaptic vesicles is sparse except of VGLUT1 and ZnT3
Neha Upmanyu, Jialin Jin, Henrik von der Emde, Marcelo Ganzella, Leon Bösche, Viveka Nand Malviya, Evi Zhuleku, Antonio Politi, Momchil Ninov, Ivan Silbern, Marcel Leutenegger, Henning Urlaub, Dietmar Riedel, Julia Preobraschenski, Ira Milosevic, Stefan W Hell, Reinhard Jahn, Sivakumar Sambandan (2022)
Prion-like α-synuclein pathology in the brain of infants with Krabbe disease
Christopher Hatton, Simona S. Ghanem, David J. Koss, Ilham Y. Abdi, Elizabeth Gibbons, Rita Guerreiro, Jose Bras, International DLB Genetics Consortium, Lauren Walker, Ellen Gelpi, Wendy Heywood, Tiago F. Outeiro, Johannes Attems, Robert McFarland, Rob Forsyth, Omar M. El-Agnaf, Daniel Erskine (2022)
Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured Cells
Eftychia Vasili, Antonio Dominguez-Meijide, Manuel Flores-León, Mohammed Al-Azzani, Angeliki Kanellidi, Ronald Melki, Leonidas Stefanis, Tiago Fleming Outeiro (2022)
Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R
Tal M. Dankovich, Rahul Kaushik, Linda HM Olsthoorn, Gabriel Cassinelli Petersen, Philipp Emanuel Giro, Verena Klüver, Paola Agüi-Gonzalez, Katharina Grewe, Guobin Bao, Sabine Beuermann, Hannah Abdul Hadi, Jose Dören, Simon Klöppner, Benjamin H. Cooper, Alexander Dityatev, Silvio O. Rizzoli (2021)
Postnatal expression of the lysine methyltransferase SETD1B is essential for learning and the regulation of neuron-enriched genes
Alexandra Michurina, M. Sadman Sakib, Cemil Kerimoglu, Dennis Manfred Krüger, Lalit Kaurani, Md Rezaul Islam, Parth Devesh Joshi, Sophie Schröder, Tonatiuh Pena Centeno, Jiayin Zhou, Ranjiit Pradhan, Julia Cha, Xingbo Xu, Gregor Eichele, Elisabeth M. Zeisberg, Andrea Kranz, A. Francis Stewart, Andre Fischer (2021).
Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy
Matthias Kettwig, Katharina Ternka, Kristin Wendland, Dennis Manfred Krüger, Silvia Zampar, Charlotte Schob, Jonas Franz, Abhishek Aich, Anne Winkler, M. Sadman Sakib, Lalit Kaurani, Robert Epple, Hauke B. Werner, Samy Hakroush,Julia Kitz, Marco Prinz, Eva Bartok, Gunther Hartmann, Simone Schröder,Peter Rehling, “..” (2021)
Optimal Precision and Accuracy in 4Pi-STORM using Dynamic Spline PSF Models
Mark Bates, Jan Keller-Findeisen, Adrian Przybylski, Andreas Hüper, Till Stephan, Peter Ilgen, Angel R. Cereceda Delgado, Elisa D’Este, Stefan Jakobs, Steffen J. Sahl, Stefan W. Hell (2021)
Published 19. October 2021
BioRixV
https://doi.org/10.1101/2021.10.19.464803
now published 16. May 2022, Nat Meth
http://dx.doi.org/10.1038/s41592-022-01465-8
Exercise as a model to identify microRNAs linked to human cognition: a role for microRNA-409 and microRNA-501
Maria Goldberg, Md Rezaul Islam, Cemil Kerimoglu, Camille Lancelin, Verena Gisa, Susanne Burkhardt, Dennis M. Krüger, Till Marquardt, Berend Malchow, Andrea Schmitt, Peter Falkai, Farahnaz Sananbenesi, Andre Fischer (2021)
Cellular Prion Protein Mediates α-Synuclein Uptake, Localization, and Toxicity In Vitro and In Vivo
Tobias Thom, Matthias Schmitz, Anna-Lisa Fischer, Angela Correia, Susana Correia, Franc Llorens, Anna-Villar Pique, Wiebke Möbiu, Renato Domingues, Saima Zafar, Erik Stoops, Christopher J. Silva, Andre Fischer, Tiago F. Outeiro, Inga Zerr (2021)
Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease
Luis M. A. Oliveira,Thomas Gasser,Robert Edwards,Markus Zweckstetter,Ronald Melki,Leonidas Stefanis,Hilal A. Lashuel,David Sulzer, Kostas Vekrellis, Glenda M. Halliday,Julianna J. Tomlinson,Michael Schlossmacher,Poul Henning Jensen,Julia Schulze-Hentrich,Olaf Riess,Warren D. Hirst,Omar El-Agnaf,Brit Mollenhauer,Peter Lansbury, Tiago F. Outeiro (2021)
A large-scale nanoscopy and biochemistry analysis of postsynaptic dendritic spines
Martin S. Helm, Tal M. Dankovich, Sunit Mandad, Burkhard Rammner, Sebastian Jähne, Vanessa Salimi, Christina Koerbs, Richard Leibrandt, Henning Urlaub, Thomas Schikorski, Silvio O. Rizzoli (2021)
Low-Expressing Synucleinopathy Mouse Models Based on Oligomer-Forming Mutations and C-Terminal Truncation of α-Synuclein
Ana Martinez Hernandez, Ivan Silbern, Insa Geffers, Lars Tatenhorst, Stefan Becker, Henning Urlaub, Markus Zweckstetter, Christian Griesinger, Gregor Eichele (2021)
Alpha-synuclein induces epigenomic dysregulation of glutamate signaling and locomotor pathways
Samantha L. Schaffner, Zinah Wassouf, Diana F. Lazaro, Mary Xylaki, Nicole Gladish, David T. S. Lin, Julia MacIsaac, Katia Ramadori, Julia M. Schulze-Hentrich, Tiago F. Outeiro, Michael S. Kobor (2021)
Relative Quantification of Phosphorylated and Glycosylated Peptides from the Same Sample Using Isobaric Chemical Labelling with a Two-Step Enrichment Strategy
Ivan Silbern, Pan Fang, Yanlong Ji, Lenz Christof, Henning Urlaub, Kuan-Ting Pan (2021)
Super-resolution microscopy informs on the molecular architecture of alpha-synuclein inclusions in model systems and in the human brain
Patrick Weish, Diana F. Lázaro, Luís Palmares, Patrícia I. Santos, Christine Stadelmann, Günter U. Höglinger, Silvio O. Rizzoli, Tiago F. Outeiro (2021)
Secondary Ion Mass Spectrometry Imaging Reveals Changes in the Lipid Structure of the Plasma Membranes of Hippocampal Neurons following Drugs Affecting Neuronal Activity
Paola Agüi-Gonzalez, Bao Guobin, Maria A. Gomes de Castro, Silvio O. Rizzoli, and Nhu T. N. Phan (2021)
Christian Hoffmann, Roberto Sansevrino, Giuseppe Morabito, Chinyere Logan, R. Martin Vabulas, Ayse Ulusoy, Marcelo Ganzella, Dragomir Milovanovic (2021)
Sulthiame impairs mitochondrial function in vitro and may trigger onset of visual loss in Leber hereditary optic neuropathy
Marie-Christine Reinert, David Pacheu Grau, Claudia B. Catarino, Thomas Klopstock, Andreas Ohlenbusch, Michael Schittkowski, Ekkehard Wilichowski , Peter Rehling, Knut Brockmann (2021)
Cofilin pathology is a new player on α-synuclein-induced spine impairment in models of hippocampal synucleinopathy
Oliveira da Silva MI, Santejo M, Babcock IW, Magalhães A, Minamide LS, Castillo E Gerhardt E, Fahlbusch C, Swanson RA, Outeiro TF, Bamburg JR, Liz MA (2021)
Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation
Mehrnoosh Jafari, Adrian-Minh Schumacher, Nicolas Snaidero, +13, Fred Wolf, Mario Kreutzfeldt, Ruben Portugues, Doron Merkler, Thomas Misgeldm, Mattin Kerschensteiner (2021)
Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R
Tal M. Dankovich, Rahul Kaushik, Gabriel Cassinelli Petersen, Philipp Emanuel Giro, Hannah Abdul Hadi, Guobin Bao, Sabine Beuermann, Benjamin H. Cooper, Alexander Dityatev, Silvio O. Rizzoli (2020)
Published 12. November 2020
BioRxiv
https://doi.org/10.1101/2020.11.11.377515
now published 8. December 2021, Nat Comm
https://doi.org/10.1038/s41467-021-27462-7
Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo
Antonio Dominguez-Meijide, Valeria Parrales, Eftychia Vasili, Florencia González-Lizárraga, Annekatrin König, Diana F. Lázaro, Annie Lannuzel, Stéphane Haik, Elaine Del Bel, Rosana Chehín, Rita Raisman-Vozari, Patrick P. Michel, Nicolas Bizat, Tiago F Outeiro (2020)
Published 7. November 2020
BioRxiv
http://dx.doi.org/10.1101/2020.11.06.371229
Now published 8. Januar 2021, Neurobiol Dis
http://dx.doi.org/10.1016/j.nbd.2021.105256
Neuropathology of patients with COVID-19 in Germany: a post-mortem case series
Jakob Matschke, Marc Lütgehetmann, Christian Hagel, Jan P Sperhake, Ann Sophie Schröder, Carolin Edler, Herbert Mushumba, Antonia Fitzek, Lena Allweiss, Maura Dandri, Matthias Dottermusch, Axel Heinemann, Susanne Pfefferle, Marius Schwabenland, Daniel Sumner Magruder, Stefan Bonn, Marco Prinz, Christian Gerloff, Klaus Püschel, Susanne Krasemann, Martin Aepfelbacher, Markus Glatzel (2020)
Increased expression of myelin-associated genes in frontal cortex of SNCA overexpressing rats and Parkinson's disease patients.
Thomas Hentrich, Zinah Wassouf, Christine Ehrhardt, Eva Haas, James D Mills, Eleonora Aronica, Tiago F. Outeiro, Jeannette Hübener-Schmid, Olaf Riess, Nicolas Casadei, Julia M Schulze-Hentrich (2020)
Ultrastructural Imaging of Activity-Dependent Synaptic Membrane-Trafficking Events in Cultured Brain Slices
Cordelia Imig, Francisco José López-Murcia, Lydia Maus L, Ines H. García-Plaza, Lena S. Mortensen, Manuela Schwark, Valentin Schwarze, Julie Angibaud, U. Valentin Nägerl , Holger Taschenberger, Nils Brose, Benjamin H. Cooper (2020)
A comparative analysis of the mobility of 45 proteins in the synaptic bouton
Sofiia Reshetniak, Jan-Eike Ußling, Eleonora Perego, Burkhard Rammner, Thomas Schikorski, Eugenio F. Fornasiero, Sven Truckenbrodt, Sarah Köster, Silvio O. Rizzoli (2020).
A nanobody-based fluorescent reporter reveals human α-synuclein in the cell cyto-sol
Christoph Gerdes, Natalia Waal, Thomas Offner, Eugenio F Fornasiero, Nora Wender, Hannes Verbarg, Ivan Manzini, Claudia Trenkwalder, Brit Mollenhauer, Timo Strohäker, Markus Zweckstetter, Stefan Becker, Silvio O Rizzoli, Fitnat B. Basmanav, Felipe Opazo (2020).
X1INH, an improved next-generation affinity-optimized hydrazonic ligand, attenuates abnormal copper(i)/copper(ii)-α-Syn interactions and affects protein aggregation in a cellular model of synucleinopathy
Daphne S Cukierman, Diana F Lázaro, Pamela Sacco, Patricia R Ferreira, Renata Diniz , Claudio O Fernández, Tiago F Outeiro, Nicolas Rey (2020)
Circumvention of common labelling artefacts using secondary nanobodies
Shama Sograte-Idrissi, Thomas Schlichthaerle, Carlos Duque-Afonso, Mihai Alevra, Sebastian Strauss, Tobias Moser, Ralf Jungmann, Silvio O. Rizzoli, Felipe Opazo (2020)
Ultrastructural Correlates of Presynaptic Functional Heterogeneity in Hippocampal Synapses
Lydia Maus, ChoongKu Lee, Bekir Altas, Sinem M. Sertel, Kirsten Weyand, Silvio O. Rizzoli, Jeong Seop Rhee, Nils Brose, Cordelia Imig, Benjamin H. Cooper (2020)
Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors
Lin Luo, Mateusz C. Ambrozkiewicz, Fritz Benseler, Cui Chen, Emilie Dumontier, Susanne Falkner, Elisabetta Furlanis, Andrea M. Gomez, Naosuke Hoshina, Wei-Hsiang Huang, Mary Anne Hutchison, Yu Itoh-Maruoka, Laura A. Lavery, Wei Li, Tomohiko Maruo, Junko Motohashi , Emily Ling-Lin Pai, Kenneth A. Pelkey, Ariane Pereira, Thomas Philips, Jennifer L. Sinclair, Jeff A. Stogsdill, Lisa Traunmüller, Jiexin Wang, Joke Wortel, Wenjia You, Nashat Abumaria, Kevin T. Beier, Nils Brose, Harold A. Burgess, Constance L. Cepko, Jean-François Cloutie, Cagla Eroglu, Sandra Goebbels, Pascal S. Kaeser, Jeremy N. Kay, Wei L, Liqun Luo, Kenji Manda, Chris J. McBain, Klaus-Armin Nave, Marco A.M. Prado, Vania F. Prado, Jeffrey Rothstein, John L.R. Rubenstein, Gesine Saher, Kenji Sakimura, Joshua R. Sanes, Peter Scheiffele, Yoshimi Takai, Hisashi Umemori, Matthijs Verhage, Michisuke Yuzaki, Huda Yahya Zoghbi, Hiroshi Kawabe, Ann Marie Craig (2020)
Synucleinopathies: Where we are and where we need to go
Inês Caldeira Brás, Antonio Dominguez-Meijide, Ellen Gerhardt, David Koss, Diana F. Lázaro, Patrícia I. Santos, Eftychia Vasili, Mary Xylaki, Tiago Fleming Outeiro (2020)
The long noncoding RNA neuroLNC regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43
Sarva Keihani, Verena Kluever, Sunid Mandad, Vikas Bansal, Rahman R, Elisabeth Fritsch, Lucas Caldi Gomes, Annette Gärtner, Kügler S, Henning Urlaub, Jonathan D. Wren, Stefan Bonn, Silvio O. Rizzoli, Eugenio F. Fornasiero (2019)
A2A R-induced transcriptional deregulation in astrocytes: An in vitro study
Isabel Paiva, Kévin Carvalho, Patrícia Santos, Lucrezia Cellai, Maria Angeliki S. Pavlou, Gaurav Jain, Thorsten Gnad, Alexander Pfeifer, Didier Vieau, André Fischer, Luc Buée, Tiago F. Outeiro, David Blum (2019)
Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies
Éva M. Szegő, Antonio Dominguez-Meijide, Ellen Gerhardt, Anne-Katrin König, David J. Koss, WenLi, Raquel Pinho, Christiane Fahlbusch, Mary Johnson, Patricia Santos, Anna Villar-Piqué, Tobias Thom, Silvio O. Rizzoli, Matthias Schmitz, Jiayi Li, Inga Zerr, Johannes Attems, Olaf Jahn, Tiago F. Outeiro (2019)
Neuronal Redox-Imbalance in Rett Syndrome Affects Mitochondria as Well as Cytosol, and Is Accompanied by Intensified Mitochondrial O2 Consumption and ROS Release
Karolina Can, Christiane Menzfeld, Lena Rinne, Peter Rehling, Sebastian Kügler, Gocha Golubiani, Jan Dudek, Michael Müller (2019)
Seeding variability of different alpha synuclein strains in synucleinopathies
Niccolò Candelise, Matthias Schmitz, Franc Llorens, Anna Villar‐Piqué, Maria Cramm, Tobias Thom, Susana Margarida da Silva Correia, José Eriton Gomes da Cunha, Wiebke Möbius, Tiago F. Outeiro, Valentina González Álvarez, Martina Banchelli, Cristiano D’Andrea, Marella de Angelis, Saima Zafar, Alberto Rabano, Paolo Matteini, Inga Zerr (2019)
Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein
Raquel Pinho, Isabel Paiva, Kristina Gotovac Jerčić, Luis Fonseca-Ornelas, Ellen Gerhardt, Christiane Fahlbusch, Paula Garcia-Esparcia, Cemil Kerimoglu, Maria A S Pavlou, Anna Villar-Piqué, Éva Szegő, Tomás Lopes da Fonseca, Francesca Odoardi, Szabolcs Soeroes, Ana Cristina Rego, Wolfgang Fischle, Jens C Schwamborn, Thomas Meyer, Sebastian Kügler, Isidre Ferrer,
Johannes Attems, André Fischer, Stefan Becker, Markus Zweckstetter, Fran Borovecki, Tiago F Outeiro (2018
Membrane binding, internalization, and sorting of alpha-synuclein in the cell
Caterina Masaracchia,Marilena Hnida,Ellen Gerhardt,Tomás Lopes da Fonseca,Anna Villar-Pique,Tiago Branco, Markus A. Stahlberg, Camin Dean,Claudio O. Fernández,Ira Milosevic&Tiago F. Outeiro (2018)
Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi function
Isabel Paiva, Gaurav Jain, Diana F. Lázaro, Kristina Gotovac Jerčić, Thomas Hentrich, Cemil Kerimoglu, Raquel Pinho, Èva M. Szegő, Susanne Burkhardt, Vincenzo Capece, Rashi Halder, Rezaul Isla, Mary Xylaki, Lucas A. Caldi Gomes, Anna-Elisa Roser, Paul Lingor, Julia M. Schulze-Hentrich, Fran Borovečki, André Fischer, Tiago F. Outeiro (2018)
Robust nanoscopy of a synaptic protein in living mice by organic-fluorophore labeling
Jennifer-Magdalena Masch, Heinz Steffens, Joachim Fischer, Johann Engelhardt, Jasmine Hubrich, Jan Keller-Findeisen, Elisa D’Este, Nicolai T. Urban, Seth G. N. Grant, Steffen J. Sahl, Dirk Kamin, Stefan W. Hell (2018)
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