Nerve terminals contain hundreds of synaptic vesicles that form tight clusters. Despite being held together, vesicles are highly mobile within these clusters, so that they can be recruited to the membrane upon neuronal activity, for exocytosis. However, little is known about the potential mechanisms of synaptic vesicle cluster regulation. To understand this, in this project, we will analyze the dynamics and regulation of synapsin-bound vesicles both in reconstituted systems and in primary hippocampal neurons.

Dr. Dragomir Milovanovic

Dragomir Milovanovic

Principal Investigators
More subprojects

B3: “Mapping the protein and lipid organization in the plasma membrane of neurons using rapid rupture event imaging”

Andreas Janshoff

B1: “The distribution of structural lipids in synaptic membranes”

Nhu Phan

B9: “Cytoskeletal alterations contributing to synapto-axonal dysfunction in Parkinson’s disease”

Paul Lingor