A quantitative analysis of the protein composition of the synapto-axonal compartment would help to better understand the molecular basis of Parkinson’s Disease (PD), but such quantitative proteomics data of the diseased synapse are lacking so far. Although several animal models for neurodegeneration exist, it is clear that they recapitulate only part of the pathology. In this project we aim to understand the PD synapse beyond alpha-synuclein or synuclein-related elements, by revealing novel PD target proteins. We will focus especially on elements linked to the destabilization of the synapto-axonal cytoskeleton and of synapses.

Paul Lingor

Principal Investigator
More subprojects

B3: “Mapping the protein and lipid organization in the plasma membrane of neurons using rapid rupture event imaging”

Andreas Janshoff

A4: “Revealing the ultrastructural changes that determine the development of a CNS synapse”

Carolin Wichmann

B1: “The organization of structural lipids in synaptic membranes”

Nhu Phan