A quantitative analysis of the protein composition of the synapto-axonal compartment would help to better understand the molecular basis of Parkinson’s Disease (PD), but such quantitative proteomics data of the diseased synapse are lacking so far. Although several animal models for neurodegeneration exist, it is clear that they recapitulate only part of the pathology. In this project we aim to understand the PD synapse beyond alpha-synuclein or synuclein-related elements, by revealing novel PD target proteins. We will focus especially on elements linked to the destabilization of the synapto-axonal cytoskeleton and of synapses.

Paul Lingor

Principal Investigator
More subprojects

A8: “Regulation of synaptic vesicle cycling by protein phosphorylation and dephosphorylation”

Reinhard Jahn/Henning Urlaub

A6: “Mitochondria function and turnover in synapses”

Peter Rehling

B6: “The role of RNA in synapse physiology and neurodegeneration”

André Fischer/Tiago Outeiro