The calyces of the auditory system offer a direct and fascinating functional link between function and morphology. During auditory system maturation from pre-hearing to hearing states, calyceal synapses undergo striking structural, functional, and molecular changes to establish high-frequency rate signaling. In the planned project, we aim to investigate the morphological changes taking place at calyceal terminals in toto and at individual release sites by serial-block-face scanning electron microscopy (SBF-SEM), along with focused-ion-beam (FIB) SEM.

Carolin Wichmann

Principal Investigator
More subprojects

B5: “Quantitative molecular physiology of active zones at calyceal synapses”

Tobias Moser

A6: “Mitochondria function and turnover in synapses”

Peter Rehling

B9: “Cytoskeletal alterations contributing to synapto-axonal dysfunction in Parkinson’s disease”

Paul Lingor