Post-translational modifications by ubiquitin-like modifiers play a key role in numerous cellular processes, including synaptic transmission. Our past work, which has been based on the use of novel knock-in mouse lines that express affinity-tagged SUMOs, has revealed several aspects of the SUMO involvement in synaptic and neuronal function. We will now continue this focus, while also extending our approach to include a second ubiquitin-like modifiers, Nedd8 (neddylation).

Nils Brose

Principal Investigator
Dr. Marilyn Tirard

Marilyn Tirard

Principal Investigator
More subprojects

B3: “Mapping the protein and lipid organization in the plasma membrane of neurons using rapid rupture event imaging”

Andreas Janshoff

Z3: “Simple multi-color super-resolution imaging by 10x expansion microscopy”

Silvio Rizzoli

B1: “The distribution of structural lipids in synaptic membranes”

Nhu Phan