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Post-translational modifications by ubiquitin-like modifiers play a key role in numerous cellular processes, including synaptic transmission. Our past work, which has been based on the use of novel knock-in mouse lines that express affinity-tagged SUMOs, has revealed several aspects of the SUMO involvement in synaptic and neuronal function. We will now continue this focus, while also extending our approach to include a second ubiquitin-like modifiers, Nedd8 (neddylation).

Nils Brose

Principal Investigator
Dr. Marilyn Tirard

Marilyn Tirard

Principal Investigator
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Paul Lingor

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