Here we want to systematically investigate the impact of protein and lipid composition, curvature and lateral membrane tension on domain formation in multicomponent membranes derived from hippocampal neurons and from synaptosomes. We will map the position and aggregation state of certain proteins and lipids found in the presynaptic membrane with a non-invasive and label-free rapid rupture event imaging, force distance-based atomic force microscopy (AFM).

Andreas Janshoff

Principal Investigator
More subprojects

A4: “Revealing the ultrastructural changes that determine the development of a CNS synapse”

Carolin Wichmann

C3: “Modelling dendritic spine fluctuations”

Florentin Wörgötter

A5:“Nanoscale architecture of mitochondria in synapses”

Stefan Jakobs