Here we want to systematically investigate the impact of protein and lipid composition, curvature and lateral membrane tension on domain formation in multicomponent membranes derived from hippocampal neurons and from synaptosomes. We will map the position and aggregation state of certain proteins and lipids found in the presynaptic membrane with a non-invasive and label-free rapid rupture event imaging, force distance-based atomic force microscopy (AFM).

Andreas Janshoff

Principal Investigator
More subprojects

B1: “The organization of structural lipids in synaptic membranes”

Nhu Phan

A10: “Protein–protein interactions at the synapse monitored by quantitative protein cross-linking”

Henning Urlaub

C2: “Dual-purpose optimization theory for the synaptic vesicle cycle”

Fred Wolf