Although mitochondria are an integral part of synaptic boutons, little is known on their protein biogenesis, turnover and compositional dynamics in the synapse. During the first funding period, we found that synaptic mitochondria undergo protein biogenesis, and that this is required to maintain synaptic activity, independent of the mitochondrial ATP output. Based on our findings, we will now ask how mitochondria metabolism and turnover affects synapses, and how mitochondria are influenced by synaptic function.

Prof. Dr. Peter Rehling

Peter Rehling

Principal Investigator
Prof. Dr. Henning Urlaub

Henning Urlaub

Principal Investigator
Weitere Teilprojekte

Z3: “Simple multi-color super-resolution imaging by 10x expansion microscopy”

Silvio Rizzoli

B1: “The distribution of structural lipids in synaptic membranes”

Nhu Phan

B3: “Mapping the protein and lipid organization in the plasma membrane of neurons using rapid rupture event imaging”

Andreas Janshoff