In this project we will analyse the structure of entire organelles isolated from synapses. We will elucidate the organelle morphology and determine whether proteins are organized in form of domains on these organelles. If domains exist, we will also investigate how stereotypical these domains are, based on high throughput analysis and quantification of the corresponding distribution functions, using innovative X-ray optics and coherent X-ray imaging, in particular X-ray Free Electron Laser (FEL) radiation.

Tim Salditt

Principal Investigator
More subprojects

C3: “Modelling dendritic spine fluctuations”

Florentin Wörgötter

B3: “Mapping the protein and lipid organization in the plasma membrane of neurons using rapid rupture event imaging”

Andreas Janshoff

A10: “Protein–protein interactions at the synapse monitored by quantitative protein cross-linking”

Henning Urlaub