In this project we will analyse the structure of entire organelles isolated from synapses. We will elucidate the organelle morphology and determine whether proteins are organized in form of domains on these organelles. If domains exist, we will also investigate how stereotypical these domains are, based on high throughput analysis and quantification of the corresponding distribution functions, using innovative X-ray optics and coherent X-ray imaging, in particular X-ray Free Electron Laser (FEL) radiation.

Tim Salditt

Principal Investigator
More subprojects

B5: “Quantitative molecular physiology of active zones at calyceal synapses”

Tobias Moser

B3: “Mapping the protein and lipid organization in the plasma membrane of neurons using rapid rupture event imaging”

Andreas Janshoff

C1: “Theoretical model of activity-dependent AMPA-receptor dynamics in the synapse”

Christian Tetzlaff