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In this project we analysed the structure of synaptic vesicles by innovative X-ray methods, and found, among other findings, that synaptic vesicle structure changes strongly during neurotransmitter uptake. We also developed many technologies that will enable us, in the next funding period, to study whether proteins are organized in form of domains on the vesicles. If domains exist, we will also investigate how stereotypical these domains are, to understand the molecular organization of the vesicles. We will describe the morphology of the organelles and check whether proteins are organized into domains on these organelles. If these protein domains exist, we will also examine how stereotypical these domains are.

Tim Salditt

Principal Investigator
More subprojects

B9: “Cytoskeletal alterations contributing to synapto-axonal dysfunction in Parkinson’s disease”

Paul Lingor

B3: “Mapping the protein and lipid organization in the plasma membrane of neurons using rapid rupture event imaging”

Andreas Janshoff

Z3: “Simple multi-color super-resolution imaging by 10x expansion microscopy”

Silvio Rizzoli