In this project we will analyse the structure of entire organelles isolated from synapses. We will elucidate the organelle morphology and determine whether proteins are organized in form of domains on these organelles. If domains exist, we will also investigate how stereotypical these domains are, based on high throughput analysis and quantification of the corresponding distribution functions, using innovative X-ray optics and coherent X-ray imaging, in particular X-ray Free Electron Laser (FEL) radiation.

Tim Salditt

Principal Investigator
More subprojects

A1: “The ultrastructure of synapses in action”

Benjamin Cooper

A9: “SUMOylation in synapses”

Nils Brose

B4: “In vitro reconstitution of inhibitory GABAergic postsynapses”

Claudia Steinem