Mitochondria are essential for neuronal growth, survival and synaptic function. They exhibit complex mobility behaviors, and accumulating evidence suggests that their shape and protein composition may be adapted to the specific sub-cellular needs, when mitochondria are moved from one cellular site to another. Here we aim to analyze the adaptation of mitochondria to specific neuronal sites, by combining live cell microscopy with super-resolution microscopy and electron microscopy.

Stefan Jakobs

Principal Investigator
More subprojects

C1: “Theoretical model of activity-dependent AMPA-receptor dynamics in the synapse”

Christian Tetzlaff

C3: “Modelling dendritic spine fluctuations”

Florentin Wörgötter

B2: “A microfluidic in vitro approach to study protein mobility in the synapse”

Sarah Köster/Silvio Rizzoli