Mitochondria are essential for neuronal growth, survival and synaptic function. They exhibit complex mobility behaviors, and accumulating evidence suggests that their shape and protein composition may be adapted to the specific sub-cellular needs, when mitochondria are moved from one cellular site to another. Here we aim to analyze the adaptation of mitochondria to specific neuronal sites, by combining live cell microscopy with super-resolution microscopy and electron microscopy.

Stefan Jakobs

Principal Investigator
More subprojects

B9: “Cytoskeletal alterations contributing to synapto-axonal dysfunction in Parkinson’s disease”

Paul Lingor

A1: “The ultrastructure of synapses in action”

Benjamin Cooper

Z3: “Simple multi-color super-resolution imaging by 10x expansion microscopy”

Silvio Rizzoli