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Mitochondria are essential for neuronal growth, survival and synaptic function. In the first funding period, we investigated the structural plasticity of mitochondria in cultured hippocampal neurons. An unexpected finding was that not all mitochondria contain mitochondrial DNA (nucleoids). We will now investigate the effect of the presence or absence of nucleoids on synaptic mitochondrial structure, function and turnover, as well as on synaptic function, by using multiple imaging techniques.

Prof. Dr. Stefan Jakobs

Stefan Jakobs

Principal Investigator
More subprojects

B1: “The distribution of structural lipids in synaptic membranes”

Nhu Phan

B3: “Mapping the protein and lipid organization in the plasma membrane of neurons using rapid rupture event imaging”

Andreas Janshoff

B9: “Cytoskeletal alterations contributing to synapto-axonal dysfunction in Parkinson’s disease”

Paul Lingor