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We propose to take advantage of a combination of super-resolution microscopy, electron microscopy, quantitative biochemistry, conventional (biochemical) mass spectrometry, and nanoscale imaging secondary ion mass spectrometry (NanoSIMS) to analyse the average organization of the dendritic spine, and of the postsynaptic density (PSD) at rest, during and after synaptic activity, and, in a subsequent funding period, after plasticity-inducing treatments.

Silvio Rizzoli

Principal Investigator
More subprojects

A9: “SUMOylation in synapses”

Nils Brose

B4: “In vitro reconstitution of inhibitory GABAergic postsynapses”

Claudia Steinem

A5:“Nanoscale architecture of mitochondria in synapses”

Stefan Jakobs

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