We propose to take advantage of a combination of super-resolution microscopy, electron microscopy, quantitative biochemistry, conventional (biochemical) mass spectrometry, and nanoscale imaging secondary ion mass spectrometry (NanoSIMS) to analyse the average organization of the dendritic spine, and of the postsynaptic density (PSD) at rest, during and after synaptic activity, and, in a subsequent funding period, after plasticity-inducing treatments.

Silvio Rizzoli

Principal Investigator
More subprojects

Z3: “Simple multi-color super-resolution imaging by 10x expansion microscopy”

Silvio Rizzoli

A7: “The organization of the synaptic cytoskeleton”

Elisa D’Este/Stefan Hell

C1: “Theoretical model of activity-dependent AMPA-receptor dynamics in the synapse”

Christian Tetzlaff