We propose to take advantage of a combination of super-resolution microscopy, electron microscopy, quantitative biochemistry, conventional (biochemical) mass spectrometry, and nanoscale imaging secondary ion mass spectrometry (NanoSIMS) to analyse the average organization of the dendritic spine, and of the postsynaptic density (PSD) at rest, during and after synaptic activity, and, in a subsequent funding period, after plasticity-inducing treatments.

Silvio Rizzoli

Principal Investigator
More subprojects

B6: “The role of RNA in synapse physiology and neurodegeneration”

André Fischer/Tiago Outeiro

A9: “SUMOylation in synapses”

Nils Brose

B1: “The organization of structural lipids in synaptic membranes”

Nhu Phan