Exocytosis and recovery (endocytosis) of synaptic vesicles are central ingredients of the function of the synapse. Using computer simulation of coarse-grained molecular models, we will test, under which conditions fusion can be stopped and reverted to endocytosis. The role of multiple environment parameters on the change of membrane topology will be investigated: 1) lipid properties, 2) the role of SNARE fusion proteins and fission proteins of the dynamin family, and 3) intermembrane and membrane geometry.

Prof. Dr. Marcus Müller

Marcus Müller

Principal Investigators
More subprojects

B3: “Mapping the protein and lipid organization in the plasma membrane of neurons using rapid rupture event imaging”

Andreas Janshoff

B9: “Cytoskeletal alterations contributing to synapto-axonal dysfunction in Parkinson’s disease”

Paul Lingor

B1: “The distribution of structural lipids in synaptic membranes”

Nhu Phan