Here we propose to theoretically determine the ideal design of the presynaptic vesicle cycle and release machinery, as predicted by dual purpose Pareto optimization. For this we will assume that the vesicle cycle and the release machinery have to simultaneously function in (1) efficient information transmission, and in (2) generating a chemical environment that effectively recruits, maintains and buffers functional synaptic proteins in the presynaptic compartment. We will determine the optimal design of the vesicle cycle, and we will compare it to experimental data from this CRC.

Fred Wolf

Principal Investigator
More subprojects

C1: “Theoretical model of activity-dependent AMPA-receptor dynamics in the synapse”

Christian Tetzlaff

A2: “Structure of synaptic organelles by X-ray diffraction and imaging”

Tim Salditt

A5:“Nanoscale architecture of mitochondria in synapses”

Stefan Jakobs