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The molecular and structural conditions underpinning presynaptic plasticity processes are less well understood than those involved in postsynaptic plasticity. We propose to address these questions by combining mouse genetics, organotypic hippocampal slice cultures, high-pressure freezing, freeze-substitution, and electron tomography. We will investigate and compare the 3D morphology of. Schaffer collateral and mossy fiber synapses, both at rest and during activity.

Benjamin Cooper

Principal Investigator
Weitere Teilprojekte

A8: “Regulation of synaptic vesicle cycling by protein phosphorylation and dephosphorylation”

Reinhard Jahn/Henning Urlaub

B3: “Mapping the protein and lipid organization in the plasma membrane of neurons using rapid rupture event imaging”

Andreas Janshoff

B4: “In vitro reconstitution of inhibitory GABAergic postsynapses”

Claudia Steinem

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