The molecular and structural elements that are responsible for presynaptic plasticity are still little known. To understand them, we compared during the first funding period two different types of synapses, Schaffer collateral and mossy fiber synapses, in resting conditions. We will now analyse the short- and long-term activity processes in these synapses, using a combination of mouse genetics, organotypic hippocampal slice cultures, high-pressure freezing, freeze-substitution, and electron tomography.

Dr. Benjamin Cooper Ph.D

Benjamin Cooper

Principal Investigator
Weitere Teilprojekte

B3: “Mapping the protein and lipid organization in the plasma membrane of neurons using rapid rupture event imaging”

Andreas Janshoff

Z3: “Simple multi-color super-resolution imaging by 10x expansion microscopy”

Silvio Rizzoli

B9: “Cytoskeletal alterations contributing to synapto-axonal dysfunction in Parkinson’s disease”

Paul Lingor