The molecular and structural conditions underpinning presynaptic plasticity processes are less well understood than those involved in postsynaptic plasticity. We propose to address these questions by combining mouse genetics, organotypic hippocampal slice cultures, high-pressure freezing, freeze-substitution, and electron tomography. We will investigate and compare the 3D morphology of. Schaffer collateral and mossy fiber synapses, both at rest and during activity.

Benjamin Cooper

Principal Investigator
Weitere Teilprojekte

A6: “Mitochondria function and turnover in synapses”

Peter Rehling

B9: “Cytoskeletal alterations contributing to synapto-axonal dysfunction in Parkinson’s disease”

Paul Lingor

C1: “Theoretical model of activity-dependent AMPA-receptor dynamics in the synapse”

Christian Tetzlaff