The molecular and structural elements that are responsible for presynaptic plasticity are still little known. To understand them, we compared during the first funding period two different types of synapses, Schaffer collateral and mossy fiber synapses, in resting conditions. We will now analyse the short- and long-term activity processes in these synapses, using a combination of mouse genetics, organotypic hippocampal slice cultures, high-pressure freezing, freeze-substitution, and electron tomography.

Dr. Benjamin Cooper Ph.D

Benjamin Cooper

Principal Investigator
Weitere Teilprojekte

Z3: “Simple multi-color super-resolution imaging by 10x expansion microscopy”

Silvio Rizzoli

B1: “The distribution of structural lipids in synaptic membranes”

Nhu Phan

B3: “Mapping the protein and lipid organization in the plasma membrane of neurons using rapid rupture event imaging”

Andreas Janshoff