Bidirectional long-term synaptic plasticity induces synaptic state transitions that establish specific synaptic properties. Based on specific phosphorylation site changes on AMPA-type glutamate receptor subunits, we identified two such state transitions. We aim to decipher the signalling pathways that lead to the phosphorylation and dephosphorylation of AMPA-type glutamate receptor complexes to express state-dependent forms of long-term synaptic plasticity. We expect that results will reveal details up to the precision of single amino acids and the identity of specific signalling complexes governing AMPA-type glutamate receptor synapse incorporation or removal.

Oliver M. Schlüter

Principal Investigators
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