The assembly of the postsynaptic transmitter sensing machinery at inhibitory nerve cell synapses requires the intimate interplay between cell adhesion proteins, scaffold and adaptor proteins, and γ-aminobutyric acid (GABA) or glycine receptors. In the last funding period, we successfully developed an in vitro membrane system allowing us to analyze part of the protein machinery. We will continue this goal here, working mainly with the proteins neuroligin-2, CB2 and gephyrin.

Claudia Steinem

Principal Investigator
More subprojects

B1: “The distribution of structural lipids in synaptic membranes”

Nhu Phan

B9: “Cytoskeletal alterations contributing to synapto-axonal dysfunction in Parkinson’s disease”

Paul Lingor

B3: “Mapping the protein and lipid organization in the plasma membrane of neurons using rapid rupture event imaging”

Andreas Janshoff