The exact molecular mechanisms of the assembly of the postsynaptic neurotransmitter reception apparatus at inhibitory synapses are only beginning to emerge. Recently, we showed that the adaptor protein collybistin operates by interacting with phosphoinositide-containing membranes. We plan to address this further at the molecular level and in a quantitative fashion, by in vitro reconstitution approaches.

Claudia Steinem

Principal Investigator
More subprojects

A5:“Nanoscale architecture of mitochondria in synapses”

Stefan Jakobs

C3: “Modelling dendritic spine fluctuations”

Florentin Wörgötter

Associated project: “Modeling of short-term plasticity of nerve-evoked EPSCs at a glutamatergic synapse”

Erwin Neher