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The exact molecular mechanisms of the assembly of the postsynaptic neurotransmitter reception apparatus at inhibitory synapses are only beginning to emerge. Recently, we showed that the adaptor protein collybistin operates by interacting with phosphoinositide-containing membranes. We plan to address this further at the molecular level and in a quantitative fashion, by in vitro reconstitution approaches.

Claudia Steinem

Principal Investigator
More subprojects

B9: “Cytoskeletal alterations contributing to synapto-axonal dysfunction in Parkinson’s disease”

Paul Lingor

A9: “SUMOylation in synapses”

Nils Brose

A2: “Structure of synaptic organelles by X-ray diffraction and imaging”

Tim Salditt

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