The exact molecular mechanisms of the assembly of the postsynaptic neurotransmitter reception apparatus at inhibitory synapses are only beginning to emerge. Recently, we showed that the adaptor protein collybistin operates by interacting with phosphoinositide-containing membranes. We plan to address this further at the molecular level and in a quantitative fashion, by in vitro reconstitution approaches.

Claudia Steinem

Principal Investigator
More subprojects

Z3: “Simple multi-color super-resolution imaging by 10x expansion microscopy”

Silvio Rizzoli

Associated project: “Modeling of short-term plasticity of nerve-evoked EPSCs at a glutamatergic synapse”

Erwin Neher

B8: “Deciphering the major alpha-synuclein-related alterations in the Parkinson’s disease synapse”

Tiago Outeiro