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The assembly of the postsynaptic transmission machinery at inhibitory neuronal synapses requires the tight interplay between cell adhesion proteins, scaffold and adaptor proteins, as well as receptors for γ-aminobutyric acid (GABA) or glycine. During the last funding period, we successfully developed an in vitro membrane system that allows us to analyze part of this protein machinery.

We will continue to pursue this objective, focusing on the interaction between the cytosolic domain of Neuroligin-2 and the proteins Gephyrin and Collybistin 2.

Claudia Steinem

Principal Investigator

More subprojects

C11: “Energy optimization as an organizing principle for protein dynamics at the synapse”

Tatjana Tchumatchenko

C9: “Linking multi-timescale dynamics in the presynapse to neural computation”

Viola Priesemann

B11 “Gating and expression of long-term synaptic plasticity as an interplay between parallel transmission sites and astrocyte signalling”

Oliver M. Schlüter