The assembly of the postsynaptic transmitter sensing machinery at inhibitory nerve cell synapses requires the intimate interplay between cell adhesion proteins, scaffold and adaptor proteins, and γ-aminobutyric acid (GABA) or glycine receptors. In the last funding period, we successfully developed an in vitro membrane system allowing us to analyze part of the protein machinery. We will continue this goal here, working mainly with the proteins neuroligin-2, CB2 and gephyrin.

Claudia Steinem

Principal Investigator
More subprojects

B9: “Cytoskeletal alterations contributing to synapto-axonal dysfunction in Parkinson’s disease”

Paul Lingor

B1: “The distribution of structural lipids in synaptic membranes”

Nhu Phan

Z3: “Simple multi-color super-resolution imaging by 10x expansion microscopy”

Silvio Rizzoli