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Accumulating evidence supports the view that neuronal damage does not originate from a single cause but rather by a multitude of independent insults that synergize to initially cause synaptic dysfunction and, eventually, to kill neuronal cells. A central pathological event in PD is the accumulation of misfolded forms of alpha-synuclein (ASYN), a presynaptic protein that appears to spread throughout the brain in a prion-like manner and to be cytotoxic. Here we will study this in hippocampal neurons in culture, based on a combination of imaging and biochemistry tools.

Tiago Outeiro

Principal Investigators
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Associated project: “Modeling of short-term plasticity of nerve-evoked EPSCs at a glutamatergic synapse”

Erwin Neher

B6: “The role of RNA in synapse physiology and neurodegeneration”

André Fischer/Tiago Outeiro

A2: “Structure of synaptic organelles by X-ray diffraction and imaging”

Tim Salditt

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