Accumulating evidence supports the view that neuronal damage does not originate from a single cause but rather by a multitude of independent insults that synergize to initially cause synaptic dysfunction and, eventually, to kill neuronal cells. A central pathological event in PD is the accumulation of misfolded forms of alpha-synuclein (ASYN), a presynaptic protein that appears to spread throughout the brain in a prion-like manner and to be cytotoxic. Here we will study this in hippocampal neurons in culture, based on a combination of imaging and biochemistry tools.

Tiago Outeiro

Principal Investigators
More subprojects

A5:“Nanoscale architecture of mitochondria in synapses”

Stefan Jakobs

B9: “Cytoskeletal alterations contributing to synapto-axonal dysfunction in Parkinson’s disease”

Paul Lingor

A2: “Structure of synaptic organelles by X-ray diffraction and imaging”

Tim Salditt