Inhalt

Based on a quantitative analysis of the pre- and postsynapse, as performed during the first funding period, we propose that a novel mechanism of extracellular matrix (ECM) remodelling has a strong link to synaptic stability and plasticity. We will therefore monitor pre- and postsynaptic structural dynamics, while inducing plasticity-related changes, in control conditions or under perturbation of ECM remodelling. These experiments will also target the mechanisms of ECM remodelling, at the synapse and whole-cell levels.