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This project t is based on the working hypothesis that the drive to save energy shapes the molecular localisation and copy numbers of mRNAs and proteins across synapses, dendrites and axons. We hypothesize that energy saving strategies are imprinted on the molecular response to plasticity events and on the spatial localisation of energy-providing mitochondria in the neural processes. To understand how synaptic function is shaped by both functional and energetic constrains, we propose the following aims:

1. Analyse how the group of synapse-enriched proteins are localized under energetic constraints
2. Investigate how plasticity-related protein demands are met across space and time
3. Probe the spatial distribution of mitochondria for signatures of synaptic energy minimization